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Biological membrane that separates the interior of a cell from its outside environment

Illustration of a cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a that separates the of all from the (the extracellular space). It consists of a with embedded . The basic function of the cell membrane is to protect the cell from its surroundings. The cell membrane in and out of cells and organelles. In this way, it is to and In addition, cell membranes are involved in a variety of cellular processes such as , and and serve as the attachment surface for several extracellular structures, including the , the carbohydrate layer called the , and the intracellular network of protein fibers called the . In the field of synthetic biology, cell membranes can be .

Contents

History

Main article:

While ’s discovery of cells in 1665 led to the proposal of the , Hooke misled the that all cells contained a hard cell wall since only plant cells could be observed at the time. Microscopists focused on the cell wall for well over 150 years until advances in microscopy were made. In the early 19th century, cells were recognized as being separate entities, unconnected, and bound by individual cell walls after it was found that plant cells could be separated. This theory extended to include animal cells to suggest a universal mechanism for cell protection and development. By the second half of the 19th century, microscopy was still not advanced enough to make a distinction between cell membranes and cell walls. However, some microscopists correctly identified at this time that while invisible, it could be inferred that cell membranes existed in animal cells due to intracellular movement of components internally but not externally and that membranes weren’t the equivalent of a cell wall to plant cell. It was also inferred that cell membranes weren’t vital components to all cells. Many refuted the existence of a cell membrane still towards the end of the 19th century. In 1890, an update to the Cell Theory stated that cell membranes existed, but were merely secondary structures. It wasn’t until later studies with osmosis and permeability that cell membranes gained more recognition. In 1895, proposed that cell membranes were made of lipids.

The lipid bilayer hypothesis, proposed in 1925 by and Grendel, created speculation to the description of the cell membrane bilayer structure based on crystallographic studies and soap bubble observations. In an attempt to accept or reject the hypothesis, researchers measured membrane thickness. In 1925 it was determined by Fricke that the thickness of erythrocyte and yeast cell membranes ranged between 3.3 and 4 nm, a thickness compatible with a lipid monolayer. The choice of the dielectric constant used in these studies was called into question but future tests could not disprove the results of the initial experiment. Independently, the leptoscope was invented in order to measure very thin membranes by comparing the intensity of light reflected from a sample to the intensity of a membrane standard of known thickness. The instrument could resolve thicknesses that depended on pH measurements and the presence of membrane proteins that ranged from 8.6 to 23.2 nm, with the lower measurements supporting the lipid bilayer hypothesis. Later in the 1930s, the membrane structure model developed in general agreement to be the of and (1935). This model was based on studies of surface tension between oils and eggs. Since the surface tension values appeared to be much lower than would be expected for an oil–water interface, it was assumed that some substance was responsible for lowering the interfacial tensions in the surface of cells. It was suggested that a lipid bilayer was in between two thin protein layers. The paucimolecular model immediately became popular and it dominated cell membrane studies for the following 30 years, until it became rivaled by the fluid mosaic model of and (1972).

Despite the numerous models of the cell membrane proposed prior to the , it remains the primary archetype for the cell membrane long after its inception in the 1970s. Although the has been modernized to detail contemporary discoveries, the basics have remained constant: the membrane is a lipid bilayer composed of hydrophilic exterior heads and a hydrophobic interior where proteins can interact with hydrophilic heads through polar interactions, but proteins that span the bilayer fully or partially have hydrophobic amino acids that interact with the non-polar lipid interior. The not only provided an accurate representation of membrane mechanics, it enhanced the study of hydrophobic forces, which would later develop into an essential descriptive limitation to describe biological .

For many centuries, the scientists cited disagreed with the significance of the structure they were seeing as the cell membrane. For almost two centuries, the membranes were seen but mostly disregarded this as an important structure with cellular function. It was not until the 20th century that the significance of the cell membrane as it was acknowledged. Finally, two scientists Gorter and Grendel (1925) made the discovery that the membrane is “lipid-based”. From this, they furthered the idea that this structure would have to be in a formation that mimicked layers. Once studied further, it was found by comparing the sum of the cell surfaces and the surfaces of the lipids, a 2:1 ratio was estimated; thus, providing the first basis of the bilayer structure known today. This discovery initiated many new studies that arose globally within various fields of scientific studies, confirming that the structure and functions of the cell membrane are widely accepted.

The structure has been variously referred to by different writers as the ectoplast (, 1885),Plasmahaut (plasma skin, , 1877, 1891),Hautschicht (skin layer, Pfeffer, 1886; used with a different meaning by , 1867), plasmatic membrane (Pfeffer, 1900), plasma membrane, cytoplasmic membrane, cell envelope and cell membrane. Some authors who did not believe that there was a functional permeable boundary at the surface of the cell preferred to use the term plasmalemma (coined by Mast, 1924) for the external region of the cell.

Composition

Cell membranes contain a variety of biological molecules, notably lipids and proteins. Composition is not set, but constantly changing for fluidity and changes in the environment, even fluctuating during different stages of cell development. Specifically, the amount of cholesterol in human primary neuron cell membrane changes, and this change in composition affects fluidity throughout development stages.

Material is incorporated into the membrane, or deleted from it, by a variety of mechanisms:

  • Fusion of intracellular with the membrane () not only excretes the contents of the vesicle but also incorporates the vesicle membrane's components into the cell membrane. The membrane may form around extracellular material that pinch off to become vesicles ().
  • If a membrane is continuous with a tubular structure made of membrane material, then material from the tube can be drawn into the membrane continuously.
  • Although the concentration of membrane components in the aqueous phase is low (stable membrane components have low solubility in water), there is an exchange of molecules between the lipid and aqueous phases.

Lipids

The cell membrane consists of three classes of lipids: , , and . The amount of each depends upon the type of cell, but in the majority of cases phospholipids are the most abundant, often contributing for over 50% of all lipids in plasma membranes. Glycolipids only account for a minute amount of about 2% and sterols make up the rest. In studies, 30% of the plasma membrane is lipid. However, for the majority of eukaryotic cells, the composition of plasma membranes is about half lipids and half proteins by weight.

The fatty chains in and usually contain an even number of carbon atoms, typically between 16 and 20. The 16- and 18-carbon fatty acids are the most common. Fatty acids may be saturated or unsaturated, with the configuration of the double bonds nearly always "cis". The length and the degree of unsaturation of fatty acid chains have a profound effect on membrane fluidity as unsaturated lipids create a kink, preventing the fatty acids from packing together as tightly, thus decreasing the (increasing the fluidity) of the membrane. The ability of some organisms to regulate by altering lipid composition is called .

The entire membrane is held together via interaction of hydrophobic tails, however the structure is quite fluid and not fixed rigidly in place. Under phospholipid molecules in the cell membrane are in the . It means the lipid molecules are free to diffuse and exhibit rapid lateral diffusion along the layer in which they are present. However, the exchange of phospholipid molecules between intracellular and extracellular leaflets of the bilayer is a very slow process. and caveolae are examples of -enriched microdomains in the cell membrane. Also, a fraction of the lipid in direct contact with integral membrane proteins, which is tightly bound to the protein surface is called ; it behaves as a part of protein complex.

In animal cells cholesterol is normally found dispersed in varying degrees throughout cell membranes, in the irregular spaces between the hydrophobic tails of the membrane lipids, where it confers a stiffening and strengthening effect on the membrane. Additionally, the amount of cholesterol in biological membranes varies between organisms, cell types, and even in individual cells. Cholesterol, a major component of animal plasma membranes, regulates the fluidity of the overall membrane, meaning that cholesterol controls the amount of movement of the various cell membrane components based on its concentrations. In high temperatures, cholesterol inhibits the movement of phospholipid fatty acid chains,causing a reduced permeability to small molecules and reduced membrane fluidity. The opposite is true for the role of cholesterol in cooler temperatures. Cholesterol production, and thus concentration, is up-regulated (increased) in response to cold temperature. At cold temperatures, cholesterol interferes with fatty acid chain interactions. Acting as antifreeze, cholesterol maintains the fluidity of the membrane. Cholesterol is more abundant in cold-weather animals than warm-weather animals. In plants, which lack cholesterol, related compounds called sterols perform the same function as cholesterol.

Phospholipids forming lipid vesicles

Lipid vesicles or are circular pockets that are enclosed by a lipid bilayer. These structures are used in laboratories to study the effects of chemicals in cells by delivering these chemicals directly to the cell, as well as getting more insight into cell membrane permeability. Lipid vesicles and liposomes are formed by first suspending a lipid in an aqueous solution then agitating the mixture through , resulting in a vesicle. By measuring the rate of from that of the inside of the vesicle to the ambient solution, allows researcher to better understand membrane permeability. Vesicles can be formed with molecules and ions inside the vesicle by forming the vesicle with the desired molecule or ion present in the solution. Proteins can also be embedded into the membrane through solubilizing the desired proteins in the presence of detergents and attaching them to the phospholipids in which the liposome is formed. These provide researchers with a tool to examine various membrane protein functions.

Carbohydrates

Plasma membranes also contain , predominantly , but with some glycolipids ( and ). Carbohydrates are important in the role of in eukaryotes; they are located on the surface of the cell where they recognize host cells and share information, viruses that bind to cells using these receptors cause an infection For the most part, no occurs on membranes within the cell; rather generally glycosylation occurs on the extracellular surface of the plasma membrane. The is an important feature in all cells, especially with microvilli. Recent data suggest the glycocalyx participates in cell adhesion, , and many others. The sugar is and the terminal sugar is , as the sugar backbone is modified in the . Sialic acid carries a negative charge, providing an external barrier to charged particles.

Proteins

Type Description Examples
or transmembrane proteins Span the membrane and have a hydrophilic , which interacts with internal molecules, a hydrophobic membrane-spanning domain that anchors it within the cell membrane, and a hydrophilic extracellular domain that interacts with external molecules. The hydrophobic domain consists of one, multiple, or a combination of and protein . Ion channels, , Covalently bound to single or multiple lipid molecules; hydrophobically insert into the cell membrane and anchor the protein. The protein itself is not in contact with the membrane. Attached to integral membrane proteins, or associated with peripheral regions of the lipid bilayer. These proteins tend to have only temporary interactions with biological membranes, and once reacted, the molecule dissociates to carry on its work in the cytoplasm. ,

The cell membrane has large content of proteins, typically around 50% of membrane volume These proteins are important for cell because they are responsible for various biological activities. Approximately a third of the in code specifically for them, and this number is even higher in multicellular organisms. Membrane proteins consist of three main types: Integral proteins, peripheral proteins, and lipid-anchored proteins.

As shown in the adjacent table, integral proteins are amphipathic transmembrane proteins. Examples of integral proteins include ion channels, proton pumps, and g-protein coupled receptors. Ion channels allow inorganic ions such as sodium, potassium, calcium, or chlorine to diffuse down their electrochemical gradient across the lipid bilayer through hydrophilic pores across the membrane. The electrical behavior of cells (i.e. nerve cells) are controlled by ion channels. Proton pumps are protein pumps that are embedded in the lipid bilayer that allow protons to travel through the membrane by transferring from one amino acid side chain to another. Processes such as electron transport and generating ATP use proton pumps. A G-protein coupled receptor is a single polypeptide chain that crosses the lipid bilayer seven times responding to signal molecules (i.e. hormones and neurotransmitters). G-protein coupled receptors are used in processes such as cell to cell signaling, the regulation of the production of cAMP, and the regulation of ion channels.

The cell membrane, being exposed to the outside environment, is an important site of cell–cell communication. As such, a large variety of protein receptors and identification proteins, such as , are present on the surface of the membrane. Functions of membrane proteins can also include cell–cell contact, surface recognition, cytoskeleton contact, signaling, enzymatic activity, or transporting substances across the membrane.

Most membrane proteins must be inserted in some way into the membrane. For this to occur, an N-terminus "signal sequence" of amino acids directs proteins to the , which inserts the proteins into a lipid bilayer. Once inserted, the proteins are then transported to their final destination in vesicles, where the vesicle fuses with the target membrane.

Function

A detailed diagram of the cell membrane Illustration depicting cellular diffusion

The cell membrane surrounds the of living cells, physically separating the components from the environment. The cell membrane also plays a role in anchoring the to provide shape to the cell, and in attaching to the and other cells to hold them together to form . , , most , and also have a , which provides a mechanical support to the cell and precludes the passage of .

The cell membrane is and able to regulate what enters and exits the cell, thus facilitating the of materials needed for survival. The movement of substances across the membrane can be either "", occurring without the input of cellular energy, or "", requiring the cell to expend energy in transporting it. The membrane also maintains the . The cell membrane thus works as a selective filter that allows only certain things to come inside or go outside the cell. The cell employs a number of transport mechanisms that involve biological membranes:

1. Passive and : Some substances (small molecules, ions) such as carbon dioxide (CO2) and oxygen (O2), can move across the plasma membrane by diffusion, which is a passive transport process. Because the membrane acts as a barrier for certain molecules and ions, they can occur in different concentrations on the two sides of the membrane. Diffusion occurs when small molecules and ions move freely from high concentration to low concentration in order to equilibrate the membrane. It is considered a passive transport process because it does not require energy and is propelled by the concentration gradient created by each side of the membrane. Such a concentration gradient across a semipermeable membrane sets up an for the water. Osmosis, in biological systems involves a solvent, moving through a semipermeable membrane similarly to passive diffusion as the solvent still moves with the concentration gradient and requires no energy. While water is the most common solvent in cell, it can also be other liquids as well as supercritical liquids and gases.

2. and : Transmembrane proteins extend through the lipid bilayer of the membranes; they function on both sides of the membrane to transport molecules across it. Nutrients, such as sugars or amino acids, must enter the cell, and certain products of metabolism must leave the cell. Such molecules can diffuse passively through protein channels such as in or are pumped across the membrane by . Protein channel proteins, also called permeases, are usually quite specific, and they only recognize and transport a limited variety of chemical substances, often limited to a single substance. Another example of a transmembrane protein is a cell-surface receptor, which allow cell signaling molecules to communicate between cells.

3. : Endocytosis is the process in which cells absorb molecules by engulfing them. The plasma membrane creates a small deformation inward, called an invagination, in which the substance to be transported is captured.This invagination is caused by proteins on the outside on the cell membrane, acting as receptors and clustering into depressions that eventually promote accumulation of more proteins and lipids on the cytosolic side of the membrane. The deformation then pinches off from the membrane on the inside of the cell, creating a vesicle containing the captured substance. Endocytosis is a pathway for internalizing solid particles ("cell eating" or ), small molecules and ions ("cell drinking" or ), and macromolecules. Endocytosis requires energy and is thus a form of active transport.

4. : Just as material can be brought into the cell by invagination and formation of a vesicle, the membrane of a vesicle can be fused with the plasma membrane, extruding its contents to the surrounding medium. This is the process of exocytosis. Exocytosis occurs in various cells to remove undigested residues of substances brought in by endocytosis, to secrete substances such as hormones and enzymes, and to transport a substance completely across a cellular barrier. In the process of exocytosis, the undigested waste-containing food vacuole or the secretory vesicle budded from , is first moved by cytoskeleton from the interior of the cell to the surface. The vesicle membrane comes in contact with the plasma membrane. The lipid molecules of the two bilayers rearrange themselves and the two membranes are, thus, fused. A passage is formed in the fused membrane and the vesicles discharges its contents outside the cell

Prokaryotes

are divided into two different groups, and , with bacteria dividing further into and . have both a plasma membrane and an separated by , however, other have only a plasma membrane. These two membranes differ in many aspects. The outer membrane of the gram-negative bacteria differ from other prokaryotes due to forming the exterior of the bilayer, and and phospholipids forming the interior. The outer membrane typically has a porous quality due to its presence of membrane proteins, such as gram-negative porins, which are pore-forming proteins. The inner, plasma membrane is also generally symmetric whereas the outer membrane is asymmetric because of proteins such as the aforementioned. Also, for the prokaryotic membranes, there are multiple things that can affect the fluidity. One of the major factors that can affect the fluidity is fatty acid composition. For example, when the bacteria Staphylococcus aureus was grown in 37◦C for 24h, the membrane exhibited a more fluid state instead of a gel-like state. This supports the concept that in higher temperatures, the membrane is more fluid than in colder temperatures. When the membrane is becoming more fluid and needs to become more stabilized, it will make longer fatty acid chains or saturated fatty acid chains in order to help stabilize the membrane. are also surrounded by a composed of (amino acids and sugars). Some eukaryotic cells also have cell walls, but none that are made of peptidoglycan. The outer membrane of gram negative bacteria is rich in , which are combined poly- or oligosaccharide and carbohydrate lipid regions that stimulate the cell’s natural immunity. The outer membrane can out into periplasmic protrusions under stress conditions or upon virulence requirements while encountering a host target cell, and thus such blebs may work as virulence organelles. Bacterial cells provide numerous examples of the diverse ways in which prokaryotic cell membranes are adapted with structures that suit the organism’s niche. For example, proteins on the surface of certain bacterial cells aid in their gliding motion. Many gram-negative bacteria have cell membranes which contain ATP-driven protein exporting systems.

Structures

Fluid mosaic model

According to the of and (1972), which replaced the earlier , biological membranes can be considered as a in which lipid and protein molecules diffuse more or less easily. Although the lipid bilayers that form the basis of the membranes do indeed form two-dimensional liquids by themselves, the plasma membrane also contains a large quantity of proteins, which provide more structure. Examples of such structures are protein-protein complexes, pickets and fences formed by the actin-based , and potentially .

Lipid bilayer

Diagram of the arrangement of amphipathic lipid molecules to form a . The yellow head groups separate the grey hydrophobic tails from the aqueous cytosolic and extracellular environments.

form through the process of . The cell membrane consists primarily of a thin layer of that spontaneously arrange so that the hydrophobic "tail" regions are isolated from the surrounding water while the hydrophilic "head" regions interact with the intracellular (cytosolic) and extracellular faces of the resulting bilayer. This forms a continuous, spherical . Hydrophobic interactions (also known as the ) are the major driving forces in the formation of lipid bilayers. An increase in interactions between hydrophobic molecules (causing clustering of hydrophobic regions) allows water molecules to bond more freely with each other, increasing the entropy of the system. This complex interaction can include noncovalent interactions such as , electrostatic and hydrogen bonds.

Lipid bilayers are generally impermeable to ions and polar molecules. The arrangement of hydrophilic heads and hydrophobic tails of the lipid bilayer prevent polar solutes (ex. amino acids, nucleic acids, carbohydrates, proteins, and ions) from diffusing across the membrane, but generally allows for the passive diffusion of hydrophobic molecules. This affords the cell the ability to control the movement of these substances via complexes such as pores, channels and gates. and concentrate , which carries a negative charge, on the inner membrane. Along with , this creates an extra barrier to charged moving through the membrane.

Membranes serve diverse functions in and cells. One important role is to regulate the movement of materials into and out of cells. The phospholipid bilayer structure (fluid mosaic model) with specific membrane proteins accounts for the selective permeability of the membrane and passive and active transport mechanisms. In addition, membranes in prokaryotes and in the mitochondria and chloroplasts of eukaryotes facilitate the synthesis of ATP through chemiosmosis.

Membrane polarity

See also:

Alpha intercalated cell

The apical membrane of a polarized cell is the surface of the plasma membrane that faces inward to the . This is particularly evident in and , but also describes other polarized cells, such as . The of a polarized cell is the surface of the plasma membrane that forms its basal and lateral surfaces. It faces outwards, towards the , and away from the lumen. Basolateral membrane is a compound phrase referring to the terms "basal (base) membrane" and "lateral (side) membrane", which, especially in epithelial cells, are identical in composition and activity. Proteins (such as ion channels and ) are free to move from the basal to the lateral surface of the cell or vice versa in accordance with the . join epithelial cells near their apical surface to prevent the migration of proteins from the basolateral membrane to the apical membrane. The basal and lateral surfaces thus remain roughly equivalent[] to one another, yet distinct from the apical surface.

Membrane structures

Diagram of the Cell Membrane's structures and their function.

Cell membrane can form different types of "supramembrane" structures such as , , , , focal adhesion, and different types of . These structures are usually responsible for , communication, and . They can be visualized by or . They are composed of specific proteins, such as and .

Cytoskeleton

The is found underlying the cell membrane in the cytoplasm and provides a scaffolding for membrane proteins to anchor to, as well as forming that extend from the cell. Indeed, cytoskeletal elements interact extensively and intimately with the cell membrane. Anchoring proteins restricts them to a particular cell surface — for example, the apical surface of epithelial cells that line the — and limits how far they may diffuse within the bilayer. The cytoskeleton is able to form appendage-like organelles, such as , which are -based extensions covered by the cell membrane, and , which are -based extensions. These extensions are ensheathed in membrane and project from the surface of the cell in order to sense the external environment and/or make contact with the substrate or other cells. The apical surfaces of epithelial cells are dense with actin-based finger-like projections known as , which increase cell surface area and thereby increase the absorption rate of nutrients. Localized decoupling of the cytoskeleton and cell membrane results in formation of a .

Intracellular membranes

The content of the cell, inside the cell membrane, is composed of numerous membrane-bound organelles, which contribute to the overall function of the cell. The origin, structure, and function of each organelle leads to a large variation in the cell composition due to the individual uniqueness associated with each organelle.

  • Mitochondria and chloroplasts are considered to have evolved from bacteria, known as the . This theory arose from the idea that Paracoccus and Rhodopseaudomonas, types of bacteria, share similar functions to mitochondria and blue-green algae, or cyanobacteria, share similar functions to chloroplasts. The proposes that through the course of evolution, a eukaryotic cell engulfed these 2 types of bacteria, leading to the formation of mitochondria and chloroplasts inside eukaryotic cells. This engulfment lead to the 2 membranes systems of these organelles in which the outer membrane originated from the host's plasma membrane and the inner membrane was the endosymbiont's plasma membrane. Considering that mitochondria and chloroplasts both contain their own DNA is further support that both of these organelles evolved from engulfed bacteria that thrived inside a eukaryotic cell.
  • In eukaryotic cells, the separates the contents of the nucleus from the cytoplasm of the cell. The nuclear membrane is formed by an inner and outer membrane, providing the strict regulation of materials in to and out of the nucleus. Materials move between the cytosol and the nucleus through in the nuclear membrane. If a cell’s nucleus is more active in , its membrane will have more pores. The protein composition of the nucleus can vary greatly from the cytosol as many proteins are unable to cross through pores via diffusion. Within the nuclear membrane, the inner and outer membranes vary in protein composition, and only the outer membrane is continuous with the (ER) membrane. Like the ER, the outer membrane also possesses ribosomes responsible for producing and transporting proteins into the space between the two membranes. The nuclear membrane disassembles during the early stages of mitosis and reassembles in later stages of mitosis.
  • The ER, which is part of the endomembrane system, which makes up a very large portion of the cell's total membrane content. The ER is an enclosed network of tubules and sacs, and its main functions include protein synthesis, and lipid metabolism. There are 2 types of ER, smooth and rough. The rough ER has ribosomes attached to it used for protein synthesis, while the smooth ER is used more for the processing of toxins and calcium regulation in the cell.
  • The has two interconnected round Golgi cisternae. Compartments of the apparatus forms multiple tubular-reticular networks responsible for organization, stack connection and cargo transport that display a continuous grape-like stringed vesicles ranging from 50-60 nm. The apparatus consists of three main compartments, a flat disc-shaped cisterna with tubular-reticular networks and vesicles.

Variations

The cell membrane has different lipid and protein compositions in distinct and may have therefore specific names for certain cell types.

  • in : “Sarcolemma” is the name given to the cell membrane of myocytes (also known as muscle cells). Although the sarcolemma is similar to other cell membranes, it has other functions that set it apart. For instance, the sarcolemma transmits synaptic signals, helps generate action potentials, and is very involved in muscle contractions. Unlike other cell membranes, the sarcolemma makes up small channels called “t-tubules” that pass through the entirety of muscle cells. It has also been found that the average sarcolemma is 10 m thick as opposed to the 4 m thickness of a general cell membrane.
  • Oolemma in : The oolemma of oocytes, or egg cells, are not consistent with a lipid bilayer as they lack a bilayer and do not consist of lipids. Rather, the structure has an inner layer, the fertilization envelope, and the exterior is made up of the vitelline layer, which is made up of glycoproteins; however, channels and proteins are still present for their functions in the membrane.
  • : The specialized plasma membrane on the of nerve cells that is responsible for the generation of the action potential. It consists of a granular, densely packed lipid bilayer that works closely with the cytoskeleton components spectrin and actin. These cytoskeleton components are able to bind to and interact with transmembrane proteins in the axolemma.

Permeability

See also:

The of a membrane is the rate of passive of molecules through the membrane. These molecules are known as permeant molecules. Permeability depends mainly on the and of the molecule and to a lesser extent the of the molecule. Due to the cell membrane's hydrophobic nature, small electrically neutral molecules pass through the membrane more easily than charged, large ones. The inability of charged molecules to pass through the cell membrane results in of substances throughout the of the body.

See also

Notes and references

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